Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance
Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance
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US: Oxford University Press
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English
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US: Oxford University Press
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Abstract
Human variants of the adapter protein SH2B1 are associated with severe childhood obesity, hyperphagia, and insulin resistance—phenotypes mimicked by mice lacking Sh2b1. SH2B1β and γ isoforms are expressed ubiquitously, whereas SH2B1α and δ isoforms are expressed primarily in the brain. Restoring SH2B1β driven by the neuron-specific enol...
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Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance
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TN_cdi_proquest_miscellaneous_2786814316
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2786814316
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ISSN
1945-7170,0013-7227
E-ISSN
1945-7170
DOI
10.1210/endocr/bqad032
