Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
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Author / Creator
Zheng, Danping , Mohapatra, Gayatree , Kern, Lara , He, Yiming , Shmueli, Merav D. , Valdés-Mas, Rafael , Kolodziejczyk, Aleksandra A. , Próchnicki, Tomasz , Vasconcelos, Matilde B. , Schorr, Lena , Hertel, Franziska , Lee, Ye Seul , Rufino, Miguel Camacho , Ceddaha, Emmanuelle , Shimshy, Sandy , Hodgetts, Ryan James , Dori-Bachash, Mally , Kleimeyer, Christian , Goldenberg, Kim , Heinemann, Melina , Stettner, Noa , Harmelin, Alon , Shapiro, Hagit , Puschhof, Jens , Chen, Minhu , Flavell, Richard A. , Latz, Eicke , Merbl, Yifat , Abdeen, Suhaib K. and Elinav, Eran
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable of signal sensing and inflammasome formation. Here we show that mouse
Nlrp10
is expressed in distal colonic intestinal epithelial cells (IECs) and modulated by the intestinal microbiome. In vitro,...
Alternative Titles
Full title
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Authors, Artists and Contributors
Author / Creator
Mohapatra, Gayatree
Kern, Lara
He, Yiming
Shmueli, Merav D.
Valdés-Mas, Rafael
Kolodziejczyk, Aleksandra A.
Próchnicki, Tomasz
Vasconcelos, Matilde B.
Schorr, Lena
Hertel, Franziska
Lee, Ye Seul
Rufino, Miguel Camacho
Ceddaha, Emmanuelle
Shimshy, Sandy
Hodgetts, Ryan James
Dori-Bachash, Mally
Kleimeyer, Christian
Goldenberg, Kim
Heinemann, Melina
Stettner, Noa
Harmelin, Alon
Shapiro, Hagit
Puschhof, Jens
Chen, Minhu
Flavell, Richard A.
Latz, Eicke
Merbl, Yifat
Abdeen, Suhaib K.
Elinav, Eran
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2789233726
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2789233726
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-023-01450-z
