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USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein...

USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2814527579

USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway

About this item

Full title

USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Naunyn-Schmiedeberg's archives of pharmacology, 2023-11, Vol.396 (11), p.3163-3175

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Ubiquitin-specific protease 22 (USP22) expression was reported to be increased in response to ischemic brain damage, but the biological role and underlying mechanism remain little understood. USP22 shRNA was intravenously injected into the mouse brain, and then a middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model was constructed, and...

Alternative Titles

Full title

USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2814527579

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2814527579

Other Identifiers

ISSN

0028-1298

E-ISSN

1432-1912

DOI

10.1007/s00210-023-02524-3

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