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Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's di...

Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's di...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2839250991

Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease

About this item

Full title

Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease

Publisher

United States: John Wiley & Sons, Inc

Journal title

Alzheimer's & dementia, 2024-01, Vol.20 (1), p.74-90

Language

English

Formats

Publication information

Publisher

United States: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

INTRODUCTION
Omics studies have revealed that various brain cell types undergo profound molecular changes in Alzheimer's disease (AD) but the spatial relationships with plaques and tangles and APOE‐linked differences remain unclear.
METHODS
We performed laser capture microdissection of amyloid beta (Aβ) plaques, the 50 μm halo around them,...

Alternative Titles

Full title

Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2839250991

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2839250991

Other Identifiers

ISSN

1552-5260,1552-5279

E-ISSN

1552-5279

DOI

10.1002/alz.13387

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