TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Transcription factor EB (TFEB) mediates gene expression through binding to the coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include subunits of the vacuolar ATPase (v-ATPase), which are essential for lysosome acidification. Single-nucleus RNA sequencing of wild-type and PS19 (Tau) transgenic mice expressing the P301...
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TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
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TN_cdi_proquest_miscellaneous_2892271345
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2892271345
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-023-01494-2
