Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membr...
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7 (E1), Atg3 (E2) and Atg12–Atg5–Atg16 (E3) enzymatic cascade and mediates autophagy. However, its molecular roles in autophagosome formation are still unclear. Here we show that
Saccharomyces cerevisiae
Atg8–PE and E1–E2–E3 enzymes together construct a st...
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Full title
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
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TN_cdi_proquest_miscellaneous_2899372260
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2899372260
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-023-01132-2
