Huntington's Disease: Complex Pathogenesis and Therapeutic Strategies
Huntington's Disease: Complex Pathogenesis and Therapeutic Strategies
About this item
Full title
Author / Creator
Tong, Huichun , Yang, Tianqi , Xu, Shuying , Li, Xinhui , Liu, Li , Zhou, Gongke , Yang, Sitong , Yin, Shurui , Li, Xiao-Jiang and Li, Shihua
Publisher
Switzerland: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI AG
Subjects
More information
Scope and Contents
Contents
Huntington's disease (HD) arises from the abnormal expansion of CAG repeats in the huntingtin gene (
), resulting in the production of the mutant huntingtin protein (mHTT) with a polyglutamine stretch in its N-terminus. The pathogenic mechanisms underlying HD are complex and not yet fully elucidated. However, mHTT forms aggregates and accumulate...
Alternative Titles
Full title
Huntington's Disease: Complex Pathogenesis and Therapeutic Strategies
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_3038435861
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3038435861
Other Identifiers
ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms25073845
