Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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We have previously shown that apolipoprotein E (Apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of
APOE
markedly affects the deposition of amyloid-β peptides (Aβ) in a mouse model of Alzheimer disease. Given the capacity of astrocytes to degrade Aβ, we investigated the potential role of Apoe in this ast...
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Full title
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
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TN_cdi_proquest_miscellaneous_66672848
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_66672848
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1058
