Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice
Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice
About this item
Full title
Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice
Author / Creator
Publisher
England
Journal title
The EMBO journal, 2004-09, Vol.23 (17), p.3505-3515
Language
English
Formats
Publication information
Publisher
England
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Scope and Contents
Contents
Gene-targeted mice were used to evaluate the role of the gamma isoform of phosphoinositide 3-kinase (PI3Kgamma) in dendritic cell (DC) migration and induction of specific T-cell-mediated immune responses. DC obtained from PI3Kgamma-/- mice showed a reduced ability to respond to chemokines in vitro and ex vivo and to travel to draining lymph nodes u...
Alternative Titles
Full title
Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_66835006
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_66835006
Other Identifiers
ISSN
0261-4189
