Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex
Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
HIV-1 Tat enhances viral transcription elongation by forming a ribonucleoprotein complex with transactivating responsive (TAR) RNA and P-TEFb, an elongation factor composed of cyclin T1 (CycT1) and Cdk9 that phosphorylates the C-terminal domain of RNA polymerase II. Previous studies have shown that Lys-28 in the activation domain (AD) of Tat is ess...
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Full title
Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex
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TN_cdi_proquest_miscellaneous_66990600
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_66990600
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0900012106
