Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Physiological anti-inflammatory mechanisms can potentially be exploited for the treatment of inflammatory disorders. Here we report that the neurotransmitter acetylcholine inhibits HMGB1 release from human macrophages by signaling through a nicotinic acetylcholine receptor. Nicotine, a selective cholinergic agonist, is more efficient than acetylcho...
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Full title
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
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TN_cdi_proquest_miscellaneous_67025712
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67025712
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1124
