Cytosine-5-methyltransferases add aldehydes to DNA
Cytosine-5-methyltransferases add aldehydes to DNA
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Targeted methylation of cytosine residues by
S
-adenosylmethionine–dependent DNA methyltransferases modulates gene expression in vertebrates. Here we show that cytosine-5-methyltransferases catalyze reversible covalent addition of exogenous aliphatic aldehydes to their target residues in DNA, thus yielding corresponding 5-α-hydroxyalkylcytosi...
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Full title
Cytosine-5-methyltransferases add aldehydes to DNA
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TN_cdi_proquest_miscellaneous_67271833
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67271833
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.172
