Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Inappropriate activation of the Hedgehog (Hh) signaling pathway has been implicated in a diverse spectrum of cancers, and its pharmacological blockade has emerged as an anti-tumor strategy. While nearly all known Hh pathway antagonists target the transmembrane protein Smoothened (Smo), small molecules that suppress downstream effectors could more c...
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Full title
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
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TN_cdi_proquest_miscellaneous_67611037
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67611037
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0907134106
