Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Key Points
The phosphatidylinositol 3-kinase (PI3K)–phosphatase with tensin homology (PTEN) signalling pathway is one of the most commonly altered pathways in human tumours. However, mutations of the
PTEN
gene itself account for only a fraction of these molecular changes.
The PI3K–PTEN pathway promotes cell survival and proliferation, i...
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Full title
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
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TN_cdi_proquest_miscellaneous_67693390
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67693390
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc1819
