A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
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Author / Creator
Suzuki, Nobutaka , Suzuki, Shinobu , Millar, Douglas G. , Unno, Midori , Hara, Hiromitsu , Calzascia, Thomas , Yamasaki, Sho , Yokosuka, Tadashi , Chen, Nien-Jung , Elford, Alisha R. , Suzuki, Jun-ichiro , Takeuchi, Arata , Mirtsos, Christine , Bouchard, Denis , Ohashi, Pamela S. , Yeh, Wen-Chen and Saito, Takashi
Publisher
Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Contents
IRAK-4 is a protein kinase that is pivotal in mediating signals for innate immune responses. Here, we report that IRAK-4 signaling is also essential for eliciting adaptive immune responses. Thus, in the absence of IRAK-4, in vivo T cell responses were significantly impaired. Upon T cell receptor stimulation, IRAK-4 is recruited to T cell lipid raft...
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Full title
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
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TN_cdi_proquest_miscellaneous_67816399
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67816399
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1124256
