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ArticlesPeer ReviewedFull Text
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation
Author / Creator:Iizasa, Ei’ichi ; Chuma, Yasushi ; Uematsu, Takayuki ; Kubota, Mio ; Kawaguchi, Hiroaki ; Umemura, Masayuki ; Toyonaga, Kenji ; Kiyohara, Hideyasu ; Yano, Ikuya ; Colonna, Marco ; Sugita, Masahiko ; Matsuzaki, Goro ; Yamasaki, Sho ; Yoshida, Hiroki ; Hara, Hiromitsu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-04, Vol.12 (1), p.2299-2299, Article 2299
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Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon
Author / Creator:Jeon, Seong Gyu ; Kayama, Hisako ; Ueda, Yoshiyasu ; Takahashi, Takuya ; Asahara, Takashi ; Tsuji, Hirokazu ; Tsuji, Noriko M. ; Kiyono, Hiroshi ; Ma, Ji Su ; Kusu, Takashi ; Okumura, Ryu ; Hara, Hiromitsu ; Yoshida, Hiroki ; Yamamoto, Masahiro ; Nomoto, Koji ; Takeda, Kiyoshi
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2012-05, Vol.8 (5), p.e1002714-e1002714
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CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin
Author / Creator:Ichikawa, Akihiko ; Kuba, Keiji ; Morita, Masayuki ; Chida, Shinsuke ; Tezuka, Hiroyuki ; Hara, Hiromitsu ; Sasaki, Takehiko ; Ohteki, Toshiaki ; Ranieri, V. Marco ; dos Santos, Claudia C. ; Kawaoka, Yoshihiro ; Akira, Shizuo ; Luster, Andrew D. ; Lu, Bao ; Penninger, Josef M. ; Uhlig, Stefan ; Slutsky, Arthur S. ; Imai, Yumiko
Publisher:New York, NY: American Thoracic Society
Journal title:American journal of respiratory and critical care medicine, 2013-01, Vol.187 (1), p.65-77
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Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis
Author / Creator:Mi-ichi, Fumika ; Miyamoto, Tomofumi ; Takao, Shouko ; Jeelani, Ghulam ; Hashimoto, Tetsuo ; Hara, Hiromitsu ; Nozaki, Tomoyoshi ; Yoshida, Hiroki
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-06, Vol.112 (22), p.E2884-E2890
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Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice
Author / Creator:Ishikawa, Asako ; Miyake, Yasunobu ; Kobayashi, Kimiko ; Murata, Yuzo ; Iizasa, Sayaka ; Iizasa, Ei’ichi ; Yamasaki, Sho ; Hirakawa, Naomi ; Hara, Hiromitsu ; Yoshida, Hiroki ; Yasaka, Toshiharu
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-01, Vol.9 (1), p.872-872, Article 872
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Cutaneous wound healing promoted by topical administration of heat-killed Lactobacillus plantarum KB131 and possible contribution of CARD9-mediated signaling
Author / Creator:Ishi, Shinyo ; Kanno, Emi ; Tanno, Hiromasa ; Kurosaka, Shiho ; Shoji, Miki ; Imai, Toshiro ; Yamaguchi, Kenji ; Kotsugai, Kanna ; Niiyama, Momoko ; Kurachi, Haruko ; Makabe, Fuko ; Watanabe, Takumi ; Sato, Ko ; Ishii, Keiko ; Hara, Hiromitsu ; Imai, Yoshimichi ; Kawakami, Kazuyoshi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-09, Vol.13 (1), p.15917-15917, Article 15917
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Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells
Author / Creator:Tong, Honglian ; Miyake, Yasunobu ; Mi-ichi, Fumika ; Iwakura, Yoichiro ; Hara, Hiromitsu ; Yoshida, Hiroki
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-03, Vol.13 (3), p.e0195119-e0195119
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The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Author / Creator:Hara, Hiromitsu ; Ishihara, Chitose ; Takeuchi, Arata ; Imanishi, Takayuki ; Xue, Liquan ; Morris, Stephan W ; Inui, Masanori ; Takai, Toshiyuki ; Shibuya, Akira ; Saijo, Shinobu ; Iwakura, Yoichiro ; Ohno, Naohito ; Koseki, Haruhiko ; Yoshida, Hiroki ; Penninger, Josef M ; Saito, Takashi
Publisher:New York: Nature Publishing Group US
Journal title:Nature Immunology, 2007-06, Vol.8 (6), p.619-629
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Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity
Author / Creator:Uematsu, Takayuki ; Iizasa, Ei’ichi ; Kobayashi, Noritada ; Yoshida, Hiroki ; Hara, Hiromitsu
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-12, Vol.5 (1), p.17577-17577, Article 17577
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Development of a system to analyze oral frailty associated with Alzheimer's disease using a mouse model
Author / Creator:Kuramoto, Eriko ; Kitawaki, Ayano ; Yagi, Takakazu ; Kono, Hiroshi ; Matsumoto, Shin-Ei ; Hara, Hiromitsu ; Ohyagi, Yasumasa ; Iwai, Haruki ; Yamanaka, Atsushi ; Goto, Tetsuya
Publisher:Lausanne: Frontiers Research Foundation
Journal title:Frontiers in aging neuroscience, 2022-08
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Interleukin-27 controls basal pain threshold in physiological and pathological conditions
Author / Creator:Sasaguri, Tomoko ; Taguchi, Toru ; Murata, Yuzo ; Kobayashi, Kimiko ; Iizasa, Sayaka ; Iizasa, Ei’ichi ; Tsuda, Makoto ; Hirakawa, Naomi ; Hara, Hiromitsu ; Yoshida, Hiroki ; Yasaka, Toshiharu
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-07, Vol.8 (1), p.11022-13, Article 11022
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ArticlesPeer ReviewedFull Text
The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions
Author / Creator:Tanaka, Tomokazu ; Kitajima, Yoshihiko ; Miyake, Shuusuke ; Yanagihara, Kazuyoshi ; Hara, Hiromitsu ; Nishijima-Matsunobu, Aki ; Baba, Koichi ; Shida, Masaaki ; Wakiyama, Kota ; Nakamura, Jun ; Noshiro, Hirokazu
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-09, Vol.10 (9), p.e0137257-e0137257
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ArticlesPeer ReviewedFull Text
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
Author / Creator:Zhang, Liyong ; Anglesio, Michael S ; O'Sullivan, Maureen ; Zhang, Fan ; Yang, Ge ; Sarao, Renu ; Nghiem, Mai P ; Cronin, Shane ; Hara, Hiromitsu ; Melnyk, Nataliya ; Li, Liheng ; Wada, Teiji ; Liu, Peter P ; Farrar, Jason ; Arceci, Robert J ; Sorensen, Poul H ; Penninger, Josef M
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2007-09, Vol.13 (9), p.1060-1069
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An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice
Author / Creator:Tanaka, Shuto ; Kawakita, Masataka ; Yasui, Hikaru ; Sudo, Koichi ; Itoh, Fumie ; Sasaki, Masato ; Shibata, Nobuyuki ; Hara, Hiromitsu ; Iwakura, Yoichiro ; Hashidate-Yoshida, Tomomi ; Shindou, Hideo ; Shimizu, Takao ; Oyama, Taiki ; Matsunaga, Himawari ; Takahara, Kazuhiko
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2024-06, Vol.7 (1), p.782-8, Article 782
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The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis
Author / Creator:Wada, Teiji ; Nakashima, Tomoki ; Oliveira-dos-Santos, Antonio J ; Gasser, Juerg ; Hara, Hiromitsu ; Schett, Georg ; Penninger, Josef M
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2005-04, Vol.11 (4), p.394-399
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Postnatal Syk deletion in mice clarifies the function of Syk in an anti-collagen antibody-induced arthritis model
Author / Creator:Ozaki, Naoko ; Suzuki, Shinobu ; Hara, Hiromitsu ; Yoshida, Hiroki
Publisher:BioMed Central Ltd
Journal title:Arthritis research & therapy, 2012-02, Vol.14 (S1), p.O22-O22, Article O22
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Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for β-selection and TCR repertoire formation
Author / Creator:Ishikawa, Eri ; Miyake, Yasunobu ; Hara, Hiromitsu ; Saito, Takashi ; Yamasaki, Sho
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (46), p.19979-19984
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Mincle is an ITAM-coupled activating receptor that senses damaged cells
Author / Creator:Yamasaki, Sho ; Ishikawa, Eri ; Sakuma, Machie ; Hara, Hiromitsu ; Ogata, Koji ; Saito, Takashi
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2008-10, Vol.9 (10), p.1179-1188
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Clustering of CARMA1 through SH3–GUK domain interactions is required for its activation of NF-κB signalling
Author / Creator:Hara, Hiromitsu ; Yokosuka, Tadashi ; Hirakawa, Hideki ; Ishihara, Chitose ; Yasukawa, Shinsuke ; Yamazaki, Masanori ; Koseki, Haruhiko ; Yoshida, Hiroki ; Saito, Takashi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-01, Vol.6 (1), p.5555-5555, Article 5555
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An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells
Author / Creator:Yasukawa, Shinsuke ; Miyazaki, Yoshiyuki ; Yoshii, Chika ; Nakaya, Mako ; Ozaki, Naoko ; Toda, Shuji ; Kuroda, Etsushi ; Ishibashi, Ken-ichi ; Yasuda, Tomoharu ; Natsuaki, Yohei ; Mi-ichi, Fumika ; Iizasa, Ei’ichi ; Nakahara, Takeshi ; Yamazaki, Masanori ; Kabashima, Kenji ; Iwakura, Yoichiro ; Takai, Toshiyuki ; Saito, Takashi ; Kurosaki, Tomohiro ; Malissen, Bernard ; Ohno, Naohito ; Furue, Masutaka ; Yoshida, Hiroki ; Hara, Hiromitsu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-05, Vol.5 (1), p.3755-3755, Article 3755
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Showing 1 to 20 of 30 results

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TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

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Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

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CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin

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Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis

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Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice

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Cutaneous wound healing promoted by topical administration of heat-killed Lactobacillus plantarum KB131 and possible contribution of CARD9-mediated signaling

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Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells

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The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors

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Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity

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Development of a system to analyze oral frailty associated with Alzheimer's disease using a mouse model

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Interleukin-27 controls basal pain threshold in physiological and pathological conditions

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The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions

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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

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An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice

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The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

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Postnatal Syk deletion in mice clarifies the function of Syk in an anti-collagen antibody-induced arthritis model

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Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for β-selection and TCR repertoire formation

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Mincle is an ITAM-coupled activating receptor that senses damaged cells

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Clustering of CARMA1 through SH3–GUK domain interactions is required for its activation of NF-κB signalling

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An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells

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