A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations...
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
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Author / Creator
Stephens, Philip , Edkins, Sarah , Davies, Helen , Greenman, Chris , Cox, Charles , Hunter, Chris , Bignell, Graham , Teague, Jon , Smith, Raffaella , Stevens, Claire , O'Meara, Sarah , Parker, Adrian , Tarpey, Patrick , Avis, Tim , Barthorpe, Andy , Brackenbury, Lisa , Buck, Gemma , Butler, Adam , Clements, Jody , Cole, Jennifer , Dicks, Ed , Edwards, Ken , Forbes, Simon , Gorton, Matthew , Gray, Kristian , Halliday, Kelly , Harrison, Rachel , Hills, Katy , Hinton, Jonathon , Jones, David , Kosmidou, Vivienne , Laman, Ross , Lugg, Richard , Menzies, Andrew , Perry, Janet , Petty, Robert , Raine, Keiran , Shepherd, Rebecca , Small, Alexandra , Solomon, Helen , Stephens, Yvonne , Tofts, Calli , Varian, Jennifer , Webb, Anthony , West, Sofie , Widaa, Sara , Yates, Andrew , Brasseur, Francis , Cooper, Colin S , Flanagan, Adrienne M , Green, Anthony , Knowles, Maggie , Leung, Suet Y , Looijenga, Leendert H J , Malkowicz, Bruce , Pierotti, Marco A , Teh, Bin , Yuen, Siu T , Nicholson, Andrew G , Lakhani, Sunil , Easton, Douglas F , Weber, Barbara L , Stratton, Michael R , Futreal, P Andrew and Wooster, Richard
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
Alternative Titles
Full title
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Authors, Artists and Contributors
Author / Creator
Edkins, Sarah
Davies, Helen
Greenman, Chris
Cox, Charles
Hunter, Chris
Bignell, Graham
Teague, Jon
Smith, Raffaella
Stevens, Claire
O'Meara, Sarah
Parker, Adrian
Tarpey, Patrick
Avis, Tim
Barthorpe, Andy
Brackenbury, Lisa
Buck, Gemma
Butler, Adam
Clements, Jody
Cole, Jennifer
Dicks, Ed
Edwards, Ken
Forbes, Simon
Gorton, Matthew
Gray, Kristian
Halliday, Kelly
Harrison, Rachel
Hills, Katy
Hinton, Jonathon
Jones, David
Kosmidou, Vivienne
Laman, Ross
Lugg, Richard
Menzies, Andrew
Perry, Janet
Petty, Robert
Raine, Keiran
Shepherd, Rebecca
Small, Alexandra
Solomon, Helen
Stephens, Yvonne
Tofts, Calli
Varian, Jennifer
Webb, Anthony
West, Sofie
Widaa, Sara
Yates, Andrew
Brasseur, Francis
Cooper, Colin S
Flanagan, Adrienne M
Green, Anthony
Knowles, Maggie
Leung, Suet Y
Looijenga, Leendert H J
Malkowicz, Bruce
Pierotti, Marco A
Teh, Bin
Yuen, Siu T
Nicholson, Andrew G
Lakhani, Sunil
Easton, Douglas F
Weber, Barbara L
Stratton, Michael R
Futreal, P Andrew
Wooster, Richard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_67877938
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67877938
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng1571
