TMP21 is a presenilin complex component that modulates γ-secretase but not ε-secretase activity
TMP21 is a presenilin complex component that modulates γ-secretase but not ε-secretase activity
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Author / Creator
FUSHENG CHEN , HASEGAWA, Hiroshi , WAKUTANI, Yosuke , PARDOSSI-PIQUARD, Raphaëlle , XUEYING RUAN , TANDON, Anurag , CHECLER, Frédéric , MARAMBAUD, Philippe , HANSEN, Kirk , WESTAWAY, David , ST GEORGE-HYSLOP, Peter , FRASER, Paul , SCHMITT-ULMS, Gerold , KAWARAI, Toshitaka , BOHM, Christopher , KATAYAMA, Taiichi , YONGJUN GU , SANJO, Nobuo , GLISTA, Michael and ROGAEVA, Ekaterina
Publisher
London: Nature Publishing
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English
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Publisher
London: Nature Publishing
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Contents
The presenilin proteins (PS1 and PS2) and their interacting partners nicastrin, aph-1 (refs 4, 5) and pen-2 (ref. 5) form a series of high-molecular-mass, membrane-bound protein complexes that are necessary for gamma-secretase and epsilon-secretase cleavage of selected type 1 transmembrane proteins, including the amyloid precursor protein, Notch an...
Alternative Titles
Full title
TMP21 is a presenilin complex component that modulates γ-secretase but not ε-secretase activity
Authors, Artists and Contributors
Author / Creator
HASEGAWA, Hiroshi
WAKUTANI, Yosuke
PARDOSSI-PIQUARD, Raphaëlle
XUEYING RUAN
TANDON, Anurag
CHECLER, Frédéric
MARAMBAUD, Philippe
HANSEN, Kirk
WESTAWAY, David
ST GEORGE-HYSLOP, Peter
FRASER, Paul
SCHMITT-ULMS, Gerold
KAWARAI, Toshitaka
BOHM, Christopher
KATAYAMA, Taiichi
YONGJUN GU
SANJO, Nobuo
GLISTA, Michael
ROGAEVA, Ekaterina
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_67906547
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67906547
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ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature04667
