Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion prote...
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
About this item
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The scrapie prion protein isoform, PrP
Sc
, is a prion-associated marker that seeds the conformational conversion and polymerization of normal protease-sensitive prion protein (PrP-sen). This seeding activity allows ultrasensitive detection of PrP
Sc
using cyclical sonicated amplification (PMCA) reactions and brain homogenate as a sourc...
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Full title
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
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TN_cdi_proquest_miscellaneous_68109376
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68109376
Other Identifiers
ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth1066
