A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines
A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A new line in antibiotics
Andrimid is a hybrid nonribosomal peptide-polyketide antibiotic that has been isolated from several different types of bacteria in the past twenty years. It is a nanomolar inhibitor of bacterial acetyl-CoA carboxylase, and inhibiting this enzyme blocks a step in prokaryotic fatty acid biosynthesis. Fortin
et al
....
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A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines
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TN_cdi_proquest_miscellaneous_68172496
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68172496
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature06068