The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Transformation and cancer growth are regulated by the coordinate actions of oncogenes and tumor suppressors. Here, we show that the novel E3 ubiquitin ligase
HACE1
is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of
HACE1
in mice results in the...
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Full title
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
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TN_cdi_proquest_miscellaneous_68256271
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68256271
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1621
