Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Hit where it hurts
The snag with most local anaesthetics is their lack of specificity. They are lipophilic, so can enter virtually any neuron, where they indiscriminately block sodium channels in the membrane. A way of blocking the activity of specific pain-sensing neurons without affecting other sensory or motor neurons could be used to create...
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Full title
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
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TN_cdi_proquest_miscellaneous_68341398
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68341398
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ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature06191
