Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane...
Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release
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Author / Creator
Aleardi, A M , Benard, G , Augereau, O , Malgat, M , Talbot, J C , Mazat, J P , Letellier, T , Dachary-Prigent, J , Solaini, G C and Rossignol, R
Publisher
United States
Journal title
Language
English
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Publisher
United States
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Scope and Contents
Contents
Intracellular amyloid beta-peptide (A beta) accumulation is considered to be a key pathogenic factor in sporadic Alzheimer's disease (AD), but the mechanisms by which it triggers neuronal dysfunction remain unclear. We hypothesized that gradual mitochondrial dysfunction could play a central role in both initiation and progression of sporadic AD. Th...
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Full title
Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release
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Record Identifier
TN_cdi_proquest_miscellaneous_68591896
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68591896
Other Identifiers
ISSN
0145-479X
E-ISSN
1573-6881
DOI
10.1007/s10863-005-6631-3
