Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite
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Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
Local catabolism of the amino acid tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO) is considered an important mechanism of regulating T cell immunity. We show that IDO transcription was increased when myelin-specific T cells were stimulated with tolerogenic altered self-peptides. Catabolites of Trp suppressed proliferation of myelin-specific...
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Full title
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite
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TN_cdi_proquest_miscellaneous_68769887
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68769887
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1117634
