Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progre...
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Kras
is commonly mutated in colon cancers, but mutations in
Nras
are rare. We have used genetically engineered mice to determine whether and how these related oncogenes regulate homeostasis and tumorigenesis in the colon. Expression of K-Ras
G12D
in the colonic epithelium stimulated hyperproliferation in a Mek-dependent manner. N-Ras...
Alternative Titles
Full title
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_69155401
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69155401
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.115
