Deficiency of CARD8 Is Associated with Increased Alzheimer’s Disease Risk in Women
Deficiency of CARD8 Is Associated with Increased Alzheimer’s Disease Risk in Women
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Publisher
Basel, Switzerland: S. Karger AG
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Language
English
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Publisher
Basel, Switzerland: S. Karger AG
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Contents
NF-ĸB, a major transcription factor controlling inflammation, is activated in Alzheimer’s disease (AD) brains. CARD8 protein has been implicated in the suppression of NF-ĸB activity, but a truncating polymorphism (p.C10X, rs2043211) renders a non-functional CARD8 protein that gives rise to a more active NF-ĸB and an amplification of the inflammator...
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Full title
Deficiency of CARD8 Is Associated with Increased Alzheimer’s Disease Risk in Women
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TN_cdi_proquest_miscellaneous_69676553
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69676553
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ISSN
1420-8008
E-ISSN
1421-9824
DOI
10.1159/000160956
