K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
About this item
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Author / Creator
Karapetis, Christos S , Khambata-Ford, Shirin , Jonker, Derek J , O'Callaghan, Chris J , Tu, Dongsheng , Tebbutt, Niall C , Simes, R. John , Chalchal, Haji , Shapiro, Jeremy D , Robitaille, Sonia , Price, Timothy J , Shepherd, Lois , Au, Heather-Jane , Langer, Christiane , Moore, Malcolm J and Zalcberg, John R
Publisher
Boston, MA: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
Boston, MA: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
This study examined the mutation status of the
K-ras
gene in colorectal tumors from patients who were enrolled in a trial of cetuximab, a monoclonal antibody against the epidermal growth factor receptor (EGFR). A survival benefit was found among patients with tumors bearing wild-type
K-ras
but not among patients with tumors bearing muta...
Alternative Titles
Full title
K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_69702339
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69702339
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa0804385
