Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidne...
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Inhibition of mineralcorticoid receptor activity is known to improve the outcome of chronic kidney disease. In this new report, Toshiro Fujita and his colleagues show that Rac1 strongly potentiates mineralcorticoid receptor signaling by enhancing its nuclear localization and that Rac1 inhibition is ameliorative in two rodent models of renal disease...
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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
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TN_cdi_proquest_miscellaneous_69876078
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_69876078
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1879
