Unrestrained erythroblast development in Nix⁻/⁻ mice reveals a mechanism for apoptotic modulation of...
Unrestrained erythroblast development in Nix⁻/⁻ mice reveals a mechanism for apoptotic modulation of erythropoiesis
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Normal production of RBCs requires that the antiapoptotic protein Bcl-xl be induced at end stages of differentiation in response to erythropoietin (Epo) signaling. The critical proapoptotic pathways inhibited by Bcl-xl in erythroblasts are unknown. We used gene targeting in the mouse to evaluate the BH3-only factor Nix, which is transcriptionally u...
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Full title
Unrestrained erythroblast development in Nix⁻/⁻ mice reveals a mechanism for apoptotic modulation of erythropoiesis
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TN_cdi_proquest_miscellaneous_70389641
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70389641
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0610666104
