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Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications

Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70429260

Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications

About this item

Full title

Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications

Publisher

Germany: Springer Nature B.V

Journal title

Acta neuropathologica, 2007-05, Vol.113 (5), p.559-568

Language

English

Formats

Publication information

Publisher

Germany: Springer Nature B.V

More information

Scope and Contents

Contents

The recent identification of decreased protein levels of glutamate decarboxylase (GAD) 65 and 67 isoforms in the autistic cerebellar tissue raises the possibility that abnormal regulation of GABA production in individual neurons may contribute to the clinical features of autism. Reductions in Purkinje cell number have been widely reported in autism...

Alternative Titles

Full title

Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications

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Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_70429260

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70429260

Other Identifiers

ISSN

0001-6322

E-ISSN

1432-0533

DOI

10.1007/s00401-006-0176-3

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