Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells
Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Cell-free human T-lymphotropic virus type 1 (HTLV-1) virions are poorly infectious
in vitro
for their primary target cells, CD4
+
T cells. Here, we show that HTLV-1 can efficiently infect myeloid and plasmacytoid dendritic cells (DCs). Moreover, DCs exposed to HTLV-1, both before and after being productively infected, can rapidly, effic...
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Full title
Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells
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Record Identifier
TN_cdi_proquest_miscellaneous_70482657
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70482657
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1745
