Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute m...
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The transcription factor C/EBPα (for CCAAT/enhancer binding protein-α; encoded by the gene
CEBPA
) is crucial for the differentiation of granulocytes. Conditional expression of C/EBPα triggers neutrophilic differentiation, and no mature granulocytes are observed in
Cebpa
-mutant mice. Here we identify heterozygous mutations in
CEBPA<...
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Full title
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
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TN_cdi_proquest_miscellaneous_70664543
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70664543
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/85820
