Metabolic regulation of brain Abeta by neprilysin
Metabolic regulation of brain Abeta by neprilysin
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Author / Creator
Iwata, N , Tsubuki, S , Takaki, Y , Shirotani, K , Lu, B , Gerard, N P , Gerard, C , Hama, E , Lee, H J and Saido, T C
Publisher
United States
Journal title
Language
English
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Publisher
United States
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Contents
Amyloid beta peptide (Abeta), the pathogenic agent of Alzheimer's disease (AD), is a physiological metabolite in the brain. We examined the role of neprilysin, a candidate Abeta-degrading peptidase, in the metabolism using neprilysin gene-disrupted mice. Neprilysin deficiency resulted in defects both in the degradation of exogenously administered A...
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Full title
Metabolic regulation of brain Abeta by neprilysin
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Record Identifier
TN_cdi_proquest_miscellaneous_70880130
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70880130
Other Identifiers
ISSN
0036-8075
DOI
10.1126/science.1059946
