Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
How cytokines control differentiation of helper T (TH) cells is controversial. We show that T-bet, without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies TH1 effector fate by targeting chromatin remodeling to individual interferon-gamma (IFN-gamma) alleles and by inducing IL-12 receptor beta2 expression. Subsequently, it appears t...
Alternative Titles
Full title
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
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Record Identifier
TN_cdi_proquest_miscellaneous_70939388
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_70939388
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1059835
