Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse m...
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline derivative with proven safety. After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction. As caspase-1 and nitric oxide seem to play a role in Huntington dis...
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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
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TN_cdi_proquest_miscellaneous_71219338
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71219338
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/77528
