Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Oedema factor, a calmodulin-activated adenylyl cyclase, is important in the pathogenesis of anthrax. Here we report the X-ray structures of oedema factor with and without bound calmodulin. Oedema factor shares no significant structural homology with mammalian adenylyl cyclases or other proteins. In the active site, 3′-deoxy-ATP and a single metal i...
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Full title
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
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TN_cdi_proquest_miscellaneous_71424673
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71424673
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/415396a
