Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In epithelial cells, tyrosine kinases induce the tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which induces endocytosis of E-cadherin. With a modified yeast 2-hybrid system, we isolated Hakai, an E-cadherin binding protein, which we have identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and prolin...
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Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
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TN_cdi_proquest_miscellaneous_71491864
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71491864
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1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb758
