Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related t...
Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide
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United States: Springer Nature B.V
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English
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United States: Springer Nature B.V
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Neutral endopeptidase (EC3.4.24.11, NEP, enkephalinase) is a zinc-metalloendopeptidase, cleaving a variety of substrates like enkephalins, substance P, and bradykinin. In the brain, NEP is a key enzyme in the degradation of enkephalins. Pharmacological inhibition of NEP-activity causes analgesia resulting from enhanced extracellular enkephalin conc...
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Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide
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TN_cdi_proquest_miscellaneous_71566876
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71566876
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ISSN
0895-8696
E-ISSN
0895-8696,1559-1166
DOI
10.1385/JMN:18:1-2:129
