Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Thymocyte selection and differentiation requires extracellular signal–regulated kinase (Erk) signaling, but transcription factor substrates of Erk in thymocytes are unknown. We have characterized the function of SAP-1 (
Elk4
), an Erk-regulated transcription factor, in thymocyte development. Early thymocyte development was normal, but single-...
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Full title
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
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TN_cdi_proquest_miscellaneous_71677662
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71677662
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni1038
