Increased Ionizing Radiation Sensitivity and Genomic Instability in the Absence of Histone H2AX
Increased Ionizing Radiation Sensitivity and Genomic Instability in the Absence of Histone H2AX
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To investigate the role of H2AX in mammalian cells, we generated H2AX-deficient (H2AXΔ/Δ) mouse embryonic stem (ES) cells. H2AXΔ/ΔES cells are viable. However,...
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Full title
Increased Ionizing Radiation Sensitivity and Genomic Instability in the Absence of Histone H2AX
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TN_cdi_proquest_miscellaneous_71802259
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71802259
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.122228699
