mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apop...
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition is useful in treating PTEN-null cancers. Here, we report that mTOR inhibition induced apoptosis of epithelial cells and the complete reversal of a neoplastic phenoty...
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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
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TN_cdi_proquest_miscellaneous_71970451
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_71970451
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1052
