Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb
Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The retinoblastoma tumour suppressor protein RB is cleaved by caspases during apoptosis. Here we have mutated the caspase cleavage site in the carboxy terminus of the murine Rb protein in the mouse germ line to create the
Rb-MI
allele. After endotoxic shock, expression of
Rb-MI
inhibits apoptosis in the intestines, but not in the spleen...
Alternative Titles
Full title
Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb
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TN_cdi_proquest_miscellaneous_72148261
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_72148261
Other Identifiers
ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/ncb853
