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High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a ca...

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a ca...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733347001

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

About this item

Full title

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

Publisher

Basingstoke: Elsevier Inc

Journal title

Kidney international, 2010-07, Vol.78 (1), p.48-59

Language

English

Formats

Publication information

Publisher

Basingstoke: Elsevier Inc

More information

Scope and Contents

Contents

High glucose evokes a variety of signals in mesangial cells that alter cellular functions responsible for the development of diabetic glomerulopathy. The hypoxia-inducible factor-1α (HIF-1α) regulates cellular homeostasis under hypoxic conditions, but it also has pleiotropic effects in response to cellular stresses at normoxia. Here we determined w...

Alternative Titles

Full title

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_733347001

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733347001

Other Identifiers

ISSN

0085-2538

E-ISSN

1523-1755

DOI

10.1038/ki.2010.99

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