An inosine 5′-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of myc...
An inosine 5′-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid
About this item
Full title
Author / Creator
Winnicki, W , Weigel, G , Sunder-Plassmann, G , Bajari, T , Winter, B , Herkner, H and Sengoelge, G
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mycophenolic acid (MPA) is a selective inhibitor of inosine 5′-monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme of
de novo
synthesis of guanine nucleotides. The isoenzyme IMPDH2 predominates in activated lymphocytes, and its inhibition by MPA is part of standard immunosuppressive regimens. Yet, there are significant unexplained d...
Alternative Titles
Full title
An inosine 5′-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_733589228
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733589228
Other Identifiers
ISSN
1470-269X
E-ISSN
1473-1150
DOI
10.1038/tpj.2009.43
