Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesi...
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The livers of insulin-resistant, diabetic mice manifest selective insulin resistance, suggesting a bifurcation in the insulin signaling pathway: Insulin loses its ability to block glucose production (i.e., it fails to suppress PEPCK and other genes of gluconeogenesis), yet it retains its ability to stimulate fatty acid synthesis (i.e., continued en...
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Full title
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
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TN_cdi_proquest_miscellaneous_733671852
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733671852
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0914798107
