Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs). A central event in the activation of the Fanconi anemia pathway is the mono-ubiquitylation of the FANCI-FANCD...
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Full title
Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
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TN_cdi_proquest_miscellaneous_734200353
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_734200353
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1182372
