Generation of prion transmission barriers by mutational control of amyloid conformations
Generation of prion transmission barriers by mutational control of amyloid conformations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Self-propagating β-sheet-rich protein aggregates are implicated in a wide range of protein-misfolding phenomena, including amyloid diseases and prion-based inheritance
1
. Two properties have emerged as common features of amyloids. Amyloid formation is ubiquitous: many unrelated proteins form such aggregates and even a single polypeptide can...
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Full title
Generation of prion transmission barriers by mutational control of amyloid conformations
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TN_cdi_proquest_miscellaneous_743219862
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743219862
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature01894
