MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
About this item
Full title
Author / Creator
Engelman, Jeffrey A , Zejnullahu, Kreshnik , Mitsudomi, Tetsuya , Song, Youngchul , Hyland, Courtney , Park, Joon Oh , Lindeman, Neal , Gale, Christopher-Michael , Zhao, Xiaojun , Christensen, James , Kosaka, Takayuki , Holmes, Alison J , Rogers, Andrew M , Cappuzzo, Federico , Mok, Tony , Lee, Charles , Johnson, Bruce E , Cantley, Lewis C and Jänne, Pasi A
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
The epidermal growth factor receptor (EGFR) kinase inhibitors gefitinib and erlotinib are effective treatments for lung cancers with EGFR activating mutations, but these tumors invariably develop drug resistance. Here, we describe a gefitinib-sensitive lung cancer cell line that developed resistance to gefitinib as a result of focal amplification o...
Alternative Titles
Full title
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Authors, Artists and Contributors
Author / Creator
Zejnullahu, Kreshnik
Mitsudomi, Tetsuya
Song, Youngchul
Hyland, Courtney
Park, Joon Oh
Lindeman, Neal
Gale, Christopher-Michael
Zhao, Xiaojun
Christensen, James
Kosaka, Takayuki
Holmes, Alison J
Rogers, Andrew M
Cappuzzo, Federico
Mok, Tony
Lee, Charles
Johnson, Bruce E
Cantley, Lewis C
Jänne, Pasi A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_743313910
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743313910
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1141478
