Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa
Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa
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Author / Creator
Srinivas, Nityakalyani , Jetter, Peter , Ueberbacher, Bernhard J , Werneburg, Martina , Zerbe, Katja , Steinmann, Jessica , Van der Meijden, Benjamin , Bernardini, Francesca , Lederer, Alexander , Dias, Ricardo L.A , Misson, Pauline E , Henze, Heiko , Zumbrunn, Jürg , Gombert, Frank O , Obrecht, Daniel , Hunziker, Peter , Schauer, Stefan , Ziegler, Urs , Käch, Andres , Eberl, Leo , Riedel, Kathrin , DeMarco, Steven J and Robinson, John A
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a lead compound that was active in the nanomolar range against Gra...
Alternative Titles
Full title
Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa
Authors, Artists and Contributors
Author / Creator
Jetter, Peter
Ueberbacher, Bernhard J
Werneburg, Martina
Zerbe, Katja
Steinmann, Jessica
Van der Meijden, Benjamin
Bernardini, Francesca
Lederer, Alexander
Dias, Ricardo L.A
Misson, Pauline E
Henze, Heiko
Zumbrunn, Jürg
Gombert, Frank O
Obrecht, Daniel
Hunziker, Peter
Schauer, Stefan
Ziegler, Urs
Käch, Andres
Eberl, Leo
Riedel, Kathrin
DeMarco, Steven J
Robinson, John A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_743391040
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743391040
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1182749
