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Descubrimiento de la Oceanía por los Españoles : conferencia de D. Ricardo Beltrán y Rózpide pronunciada el día 10 de Marzo de 1892

Descubrimiento de la Oceanía por los Españoles : conferencia de D. Ricardo Beltrán y Rózpide pronunciada el día 10 de Marzo de 1892 / de D. Ricardo Beltrán y Rózpide.

Piedras negras / Eugenio Fuentes.

Catholico reformado. O una declaracion que muestra quanto nos podamos.Conformar con la Iglesia Romana, tal, qual es el dia de hoy, en diversos puntos de la religion [electronic resource] : y en que puntos devamos nunca jamas convenir, sino para siempre apartarnos della. Yten, un aviso à los afficionados à la Iglesia Romana, que muestra la diche religion Romana ser contra los Catholicos rudimentos y fundamentos del catecismo. Compuesto por Guillermo Perquino licenciado en sancta theologia, y trasladado en Romance castellano por Guillermo Massan gentil-hombre, y à su costa imprimido.

Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a lead compound that was active in the nanomolar range against Gram-negative Pseudomonas spp., but was largely inactive against other Gram-negative and Gram-positive bacteria. Biochemical and genetic studies showed that the peptidomimetics had a non-membrane-lytic mechanism of action and identified a homolog of the β-barrel protein LptD (Imp/OstA), which functions in outer-membrane biogenesis, as a cellular target. The peptidomimetic showed potent antimicrobial activity in a mouse septicemia infection model. Drug-resistant strains of Pseudomonas are a serious health problem, so this family of antibiotics may have important therapeutic applications.

Science (American Association for the Advancement of Science), 2010-02, Vol.327 (5968), p.1010-1013

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

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Descubrimiento de la Oceanía por los Españoles : conferencia de D. Ricardo Beltrán y Rózpide pronunciada el día 10 de Marzo de 1892 / de D. Ricardo Beltrán y Rózpide.

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Piedras negras / Eugenio Fuentes.

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Catholico reformado. O una declaracion que muestra quanto nos podamos.Conformar con la Iglesia Romana, tal, qual es el dia de hoy, en diversos puntos de la religion [electronic resource] : y en que pu...

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Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

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